INTEGRATION OF GENOMIC ANALYSIS AND TRANSCRIPT EXPRESSION OF ABCC8 AND KCNJ11 IN FOCAL FORM OF CONGENITAL HYPERINSULINISM

Integration of genomic analysis and transcript expression of ABCC8 and KCNJ11 in focal form of congenital hyperinsulinism

BackgroundThe focal form of CHI is caused by an autosomal recessive pathogenic variant affecting the paternal homologue of genes Thumb ABCC8 or KCNJ11 and a second somatic event specifically occurring in the affected islet of Langerhans.The approach of this study was to integrate the genetic changes occurring in pancreatic focal lesions of CHI at t

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Sedimentary Characteristics and Depositional Model of Lacustrine Gravity Flows: A Case Study of Paleogene Shahejie Formation in the Gubei Sag, Eastern China

The genesis and sedimentary architecture of lacustrine gravity flow deposits include ongoing questions affecting the exploration and development of oil and gas, which require attention and investigation.Based on the core description, logging characteristics, and seismic facies in the third member of Paleogene Shahejie Integrated Washer Dryer format

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